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When men talk about using any of the oral medications for erectile dysfunction EDthey often refer to the two most popular ones as the blue pill or orange pill; that is, Viagra sildenafil or Cialis tadalafil. Both drugs belong to a group called phosphodiesterase type 5 inhibitors Cialis inhibitorswhose other members include vardenafil Levitra and Staxyn and avanafil Stendra. Basically, both Viagra and Cialis work in the same way. That is, they block the activity of an enzyme called phosphodiesterase-5 PDE5which destroys cGMP, a substance that regulates blood flow in the penis.

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